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Personalized biomedical devices & systems for healthcare applications

I-Ming CHEN, Soo Jay PHEE, Zhiqiang LUO, Chee Kian LIM

《机械工程前沿（英文）》 2011年第6卷第1期页码 3-12 doi: 10.1007/s11465-011-0209-z

摘要：

With the advancement in micro- and nanotechnology, electromechanical components and systems are getting smaller and smaller and gradually can be applied to the human as portable, mobile and even wearable devices. Healthcare industry have started to benefit from this technology trend by providing more and more miniature biomedical devices for personalized medical treatments in order to obtain better and more accurate outcome. This article introduces some recent development in non-intrusive and intrusive biomedical devices resulted from the advancement of niche miniature sensors and actuators, namely, wearable biomedical sensors, wearable haptic devices, and ingestible medical capsules. The development of these devices requires carful integration of knowledge and people from many different disciplines like medicine, electronics, mechanics, and design. Furthermore, designing affordable devices and systems to benefit all mankind is a great challenge ahead. The multi-disciplinary nature of the R&D effort in this area provides a new perspective for the future mechanical engineers.

关键词： personalized medical devices wearable sensor haptic device ingestible medical capsule

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医疗器械与新型穿戴式医疗设备的发展战略研究

程京,邢婉丽

《中国工程科学》 2017年第19卷第2期页码 68-71 doi: 10.15302/J-SSCAE-2017.02.011

摘要：

医疗器械领域涉及国计民生，发展潜力巨大，但我国医疗器械产业中低端产品较多，高端产品缺乏原创性，发展面临重重困难和挑战。作为快速增长的新兴技术领域，发展新型穿戴式医疗设备具有重要意义。为此，中国工程院启动了“我国全民健康与医药卫生事业发展战略研究”重大咨询项目，其中“医疗器械与新型穿戴式医疗设备的发展战略研究”作为八个重点课题之一，围绕医疗器械与新型穿戴式医疗设备的发展现状和战略需求，研究我国医疗器械产业与新型穿戴式医疗设备领域的现状及特点，分析我国医疗器械国产化与新型穿戴式医疗设备领域健康发展的关键问题，研究该领域的相关政策，理清我国医疗器械发展过程中的重点问题、需求、已有优势和特点，并在此基础上提出了对策建议。

关键词：医疗器械产业分析可穿戴设备发展战略

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微型医疗设备变得更智能

Chris Palmer

《工程（英文）》 2021年第7卷第1期页码 8-10 doi: 10.1016/j.eng.2020.12.004

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增材制造技术的医疗应用进展 Review

李春旭, Dario Pisignano, 赵宇, 薛佳佳

《工程（英文）》 2020年第6卷第11期页码 1222-1231 doi: 10.1016/j.eng.2020.02.018

摘要：

在过去的几十年间，增材制造（additive manufacturing, AM）技术可低成本、高效益地制造几何外形复杂的物体，在医疗行业得到了快速的发展和广泛的应用。在本文中，我们讨论了AM技术在制药学、医用植入物和医疗器械领域中的最新应用进展。口服和透皮给药的药物可以通过多种AM技术制备，不同类型的软硬医用植入物也可通过AM技术实现组织工程结构的制作。此外，利用AM技术还发明了用于诊断和治疗各种病理情况的医疗器械。越来越多的研究揭示了AM技术在医疗应用中的巨大潜力。本文目的是阐述AM技术在医学领域的应用进展以及目前的局限性。

关键词：增材制造医疗应用制药学医用植入物医疗器械

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Thermo-fluidic devices and materials inspired from mass and energy transport phenomena in biological

Jian XIAO , Jing LIU ,

《能源前沿（英文）》 2009年第3卷第1期页码 47-59 doi: 10.1007/s11708-008-0068-4

摘要： Mass and energy transport consists of one of the most significant physiological processes in nature, which guarantees many amazing biological phenomena and activities. Borrowing such idea, many state-of-the-art thermo-fluidic devices and materials such as artificial kidneys, carrier erythrocyte, blood substitutes and so on have been successfully invented. Besides, new emerging technologies are still being developed. This paper is dedicated to presenting a relatively complete review of the typical devices and materials in clinical use inspired by biological mass and energy transport mechanisms. Particularly, these artificial thermo-fluidic devices and materials will be categorized into organ transplantation, drug delivery, nutrient transport, micro operation, and power supply. Potential approaches for innovating conventional technologies were discussed, corresponding biological phenomena and physical mechanisms were interpreted, future promising mass-and-energy-transport-based bionic devices were suggested, and prospects along this direction were pointed out. It is expected that many artificial devices based on biological mass and energy transport principle will appear to better improve various fields related to human life in the near future.

关键词： bionics mass transport energy transport artificial devices and materials biology system nature phenomena medical device.

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机器学习和医疗设备——组织工程的发展趋势

Hannah A. Pearce,Antonios G. Mikos

《工程（英文）》 2021年第7卷第12期页码 1704-1706 doi: 10.1016/j.eng.2021.05.014

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Personalized medicine of type 2 diabetes

null

《医学前沿（英文）》 2013年第7卷第1期页码 1-3 doi: 10.1007/s11684-013-0241-y

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Recent development on statistical methods for personalized medicine discovery

null

《医学前沿（英文）》 2013年第7卷第1期页码 102-110 doi: 10.1007/s11684-013-0245-7

摘要：

It is well documented that patients can show significant heterogeneous responses to treatments so the best treatment strategies may require adaptation over individuals and time. Recently, a number of new statistical methods have been developed to tackle the important problem of estimating personalized treatment rules using single-stage or multiple-stage clinical data. In this paper, we provide an overview of these methods and list a number of challenges.

关键词： dynamic treatment regimes personalized medicine reinforcement learning Q-learning

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Utilizing big data to build personalized technology and system of diagnosis and treatment in traditional

null

《医学前沿（英文）》 2014年第8卷第3期页码 272-278 doi: 10.1007/s11684-014-0364-9

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Ultrasonic emulsification: basic characteristics, cavitation, mechanism, devices and application

《化学科学与工程前沿（英文）》 2023年第17卷第10期页码 1560-1583 doi: 10.1007/s11705-022-2160-4

摘要： Emulsion systems are widely applied in agriculture, food, cosmetic, pharmaceutical and biomedical industries. Ultrasound has attracted much attention in emulsion preparation, especially for nanoemulsion, due to its advantages of being eco-friendly, cost-effective and energy-efficient. This review provides an overview for readers to the area of ultrasonic emulsification technology. It briefly introduces and summarizes knowledge of ultrasonic emulsification, including emulsion characteristics, acoustic cavitation, emulsification mechanism, ultrasonic devices and applications. The combination of microfluidics and ultrasound is highlighted with huge advantages in controlling cavitation phenomena and emulsification intensification. A novel scale of dμ_C^0.6/μ_D^0.33−E_V is proposed to be able to compare the energy efficiency of emulsion preparation in different devices.

关键词： nanoemulsion ultrasound microreactor multiphase energy

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Introduction to the Special Section on Biomedical Devices for Personal Health Applications

I-Ming CHEN

《机械工程前沿（英文）》 2011年第6卷第1期页码 1-2 doi: 10.1007/s11465-011-0210-6

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A literature review of perishable medical resource management

《工程管理前沿（英文）》页码 710-726 doi: 10.1007/s42524-023-0278-9

摘要： In recent decades, healthcare providers have faced mounting pressure to effectively manage highly perishable and limited medical resources. This article offers a comprehensive review of supply chain management pertaining to such resources, which include transplantable organs and healthcare products. The review encompasses 93 publications from 1990 to 2022, illustrating a discernible upward trajectory in annual publications. The surveyed literature is categorized into three levels: Strategic, tactical, and operational. Key problem attributes and methodologies are analyzed through the assessment of pertinent publications for each problem level. Furthermore, research on service innovation, decision analytics, and supply chain resilience elucidates potential areas for future research.

关键词： perishable medical resources organ transplant healthcare products decision analytics operations management

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Clean energy technology: materials, processes and devices for electrochemical energy conversion and storage

Hong YANG, Junliang ZHANG, Baolian YI

《能源前沿（英文）》 2017年第11卷第3期页码 233-235 doi: 10.1007/s11708-017-0501-7

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Optimal portfolio design of energy storage devices with financial and physical right market

《能源前沿（英文）》 2022年第16卷第1期页码 95-104 doi: 10.1007/s11708-021-0788-2

摘要： With the continuous development of the spot market, in the multi-stage power market environment with the day-ahead market and right market, the study associated with the portfolio of energy storage devices requires that attention should be paid to transmission congestion and power congestion. To maximize the profit of energy storage and avoid the imbalance of power supply and consumption and the risk of node price fluctuation caused by transmission congestion, this paper presents a portfolio strategy of energy storage devices with financial/physical contracts. First, the concepts of financial/physical transmission rights and financial/physical storage rights are proposed. Then, the portfolio models of financial contract and physical contract are established with the conditional value-at-risk to measure the risks. Finally, the portfolio models are verified through the test data of the Pennsylvania-New Jersey-Maryland (PJM) electric power spot market, and the comparison between the risk aversion of portfolios based on financial/physical contract with the portfolio of the market without rights. The simulation results show that the portfolio models proposed in this paper can effectively avoid the risk of market price fluctuations.

关键词： portfolio node price fluctuation transmission right energy storage right risk aversion

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Bioartificial liver devices: Perspectives on the state of the art

null

《医学前沿（英文）》 2011年第5卷第1期页码 15-19 doi: 10.1007/s11684-010-0110-x

摘要：

Acute liver failure remains a significant cause of morbidity and mortality. Bioartificial liver (BAL) devices have been in development for more than 20 years. Such devices aim to temporarily take over the metabolic and excretory functions of the liver until the patients’ own liver has recovered or a donor liver becomes available for transplant. The important issues include the choice of cell materials and the design of the bioreactor. Ideal BAL cell materials should be of good viability and functionality, easy to access, and exclude immunoreactive and tumorigenic cell materials. Unfortunately, the current cells in use in BAL do not meet these requirements. One of the challenges in BAL development is the improvement of current materials; another key point concerning cell materials is the coculture of different cells. The bioreactor is an important component of BAL, because it determines the viability and function of the hepatocytes within it. From the perspective of bioengineering, a successful and clinically effective bioreactor should mimic the structure of the liver and provide an in vivo-like microenvironment for the growth of hepatocytes, thereby maintaining the cells’ viability and function to the maximum extent. One future trend in the development of the bioreactor is to improve the oxygen supply system. Another direction for future research on bioreactors is the application of biomedical materials. In conclusion, BAL is, in principle, an important therapeutic strategy for patients with acute liver failure, and may also be a bridge to liver transplantation. It requires further research and development, however, before it can enter clinical practice.

关键词： acute liver failure bioartificial livers hepatocyte bioreactor